Sermorelin Frequently Asked Questions



Is Sermorelin the same as human growth hormone (HGH)?

No, it is a growth hormone stimulator, which means it stimulates the pituitary gland to produce and secrete growth hormone. The body will only use the amount of Sermorelin it needs to manufacture a healthy amount of Human Growth Hormone (hGH).  For those who want faster results, HGH Therapy will be the preferred choice. HGH Therapy is quicker to take affect and permits for higher overall levels of HGH to be reached quickly.


I've seen ads for HGH-Human Growth Hormone releasers that don’t require a prescription. Are these the same as Sermorelin?

No, the OTC (over the counter) releasers are usually the amino acids L-arginine, L-glutamine, L-ornithine, glycine, L-dopa, as well as, such substances as ornithine alpha-ketoglutarate and the herbs Macuna pruriens and Tribulus terrestris. While high doses of these compounds sometimes elicit release of HGH from the pituitary gland, the effect is non-specific. In other words, they create a general effect on brain activity, just as exercise does, that sometimes causes HGH to be released. However, the effect is intermittent and unreliable since it does not work through any receptor specific process on the pituitary gland. Also, high doses of amino acids can produce kidney problems presenting a risk for the regular use of such products. In contrast, Sermorelin initiates its action exactly the same as that used by naturally occurring growth hormone releasing hormone. Furthermore, Sermorelin has an excellent safety profile with little side effects.


If HGH-Human Growth Hormone is effective in addressing adult growth hormone deficiency, why should I consider Sermorelin?

For several reasons Sermorelin is a better choice.  It is safer, less expensive, very few side effects and you cannot overdose because it works naturally with your pituitary. Sermorelin produces the same effects on body composition and provides the benefits of HGH, but in addition, it's effects are regulated at the level of the pituitary gland by negative feedback and by release of somatostatin (a hormone that is widely distributed throughout the body, especially in the hypothalamus and pancreas, that acts as an important regulator of endocrine and nervous system function by inhibiting the secretion of several other hormones such as growth hormone, insulin, and gastrin). This way the safety concerns associated with HGH overdosing are minimized or completely avoided.

Tissue exposure to HGH released by the pituitary under the influence of Sermorelin mimics the body’s normal physiology. This means HGH is released as needed by the body not at a steady amount like when HGH is used.  When dosing with HGH a specific amount is given each day if needed or not. By stimulating the pituitary it preserves more of the growth hormone neuroendocrine axis that is the first to fail during aging.

Sermorelin actually awakens the pituitary gland and unblocks hormone failure that occurs earlier in life due to aging thereby restoring and preserving youthful anatomy and physiology.  It provides the patient with all the benefits of HGH replacement.


In children, Sermorelin acetate (GHRH) is FDA approved for ramping up growth hormone levels in children who do not make enough Groth Hormone and are deficient. It is on-label and FDA approved for this indication.

In adults, using it to increase growth hormone and IGF-1 levels, Sermorelin is an off-label use of this product. This means it can be prescribed by physicians who determine an indication to be appropriate, but it was not cleared by the FDA specifically for this purpose.


Must Sermorelin be injected just as is required for HGH?

Currently, the only method for effectively administering  Sermorelin is by subcutaneous injection. However, because the molecule is much smaller than HGH, it may someday be possible to successfully administer it through the nasal mucousa using a spray formulation.


Are the effective dosages of HGH and Sermorelin comparable?

Although they work on different sites in the body (HGH at the liver and Sermorelin at the pituitary), the amount of each needed to be effective are approximately the same.  


Are the costs for HGH and Sermorelin comparable?

No. Sermorelin is significantly less expensive, 2x longer lasting and safer than HGH.  Often, the effects of HGH fade after several months of use.


What causes that loss of potency and does it also occur for Sermorelin?

HGH losses potency after six months of continuous use because of the fact the it elevates the blood levels of the hormone to unnaturally high values for several hours each day and causes constant stimulation and production of IGF-1 (this does not occur under normal conditions) In an attempt to correct what is happening the body tries to fight what is happening. Sermorelin causes your body to create HGH naturally allowing stimultation to be on and off which is the natural process.  The body is creating HGH naturally so it will regulate naturally and you don't have to worry about the body not responding at any point.


Is there a standard protocol for prescribing Sermorelin?

Sermorelin is administered by injection once daily prior to bedtime.   You have to take in on an empty stomach which means 2 hours away from food, and once you are in bed no snacks after going to sleep. Dose selection should be suited for each person's individual needs. 


What BENEFITS can I Expect?

Increase in energy, sex drive, skin elasticity, muscle tone, stamina, focus, bone density, and mental functions. Patients can also expect to experience deeper, more restful sleep, fuller hair, and improved recovery time from wounds and illnesses. Also you should see a decrease in fat, wrinkles, cholesterol, cellulite, joint and muscle pain, fatigue and depression.


To completely appreciate the benefits of Sermorelin, first it is necessary to understand Human Growth Hormone (HGH). HGH is secreted by the pituitary gland and controls the growth of cells and organs in the body.

Natural HGH peaks at age 20. Beginning at age 30, humans experience a 14% reduction in HGH every decade of life. By age 40, the production of the human growth hormone is only 40% of what it was at 20. It is possible to stimulate the pituitary gland to produce HGH again, even after this decline in production has occurred, by using a Growth Hormone Releasing Factor (GRF) like Sermorelin.


GHRH- Sermorelin for injection was approved in the treatment of growth hormone deficiency in children by the FDA in 1997. This therapy consists of daily injections of Sermorelin acetate which stimulates the pituitary gland to increase the natural secretion of human growth hormone. Since Sermorelin acetate is approved as safe for use in children to increase their production of growth hormone, it is considered safe for use in increasing the natural production of growth hormone in adults deficient in growth hormone.


This treatment is prescribed for unlabeled use in adults to increase lean muscle mass, reduce body fat, increase bone density, enhance the immune system, and strengthen the heart, as well as, other organs of the body. Since the increased volume of human growth hormone is produced by the body’s pituitary gland, the body’s endocrine system will not allow more growth hormone to be produced by the Sermorelin GH-RH stimulation of the pituitary than the body can safely process within the endocrine self-monitoring system.


Unlike HGH the Human Growth Hormone itself, Sermorelin affects a more primary source of failure in the GH neuroendocrine axis, has more physiological activity, has a better safety profile, and its use for adult hormone deficiency is not restricted.


How long does it take before it starts working?

Sermorelin just like HGH is excreted from the body very quickly so they must be injected on a frequent basis.  Sermorelin has a loading period of 3 to 6 months before full effects can be seen but a lot of patients start to notice results such as better sleep within just two weeks. 


Will I have to take Semorelin FOREVER?

No, once optimal levels of HGH are reached they can be sustained for a long time after the last injection.  This means the injections can be altered to decreased frequencies or stopped all together.


What is the cost of Semorelin? 

It depends on which product you choose. Approximately $200 per month and you should plan on committing to 6 months of therapy to have best chance of maximum anti-aging benefits.  There is a discount for buying 3 or 6 months at a time.